Beilstein J. Org. Chem.2019,15, 2544–2551, doi:10.3762/bjoc.15.247
reported for solonamides.
Keywords: antivirulencedrug; bacteria; macrocyclization; pathoblocker; quorum quenching; Introduction
The cyclodepsipeptides called solonamides A and B are natural molecules extracted from the marine bacterium Photobacterium halotolerans [1][2] (Figure 1). They are able to
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Graphical Abstract
Figure 1:
Chemical structure of solonamides and autoinducing peptides (AIP).
Beilstein J. Org. Chem.2018,14, 2607–2617, doi:10.3762/bjoc.14.239
market with an antivirulencedrug. The monoclonal antibody bezlotoxumab binds to C. difficile toxin B and was approved for the prevention of infections with this intestinal pathogen in 2016 [52]. Obiltoxaximab [53] and raxibacumab [54] are two approved antibody treatments for inhalative anthrax that
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Graphical Abstract
Figure 1:
Mannosides as inhibitors of the lectin FimH from uropathogenic Escherichia coli.